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It is not clear whether life has to “advance,” whether evolution must take place, if there is a satisfactory status quo. Brachiopods, lampshells, for instance, have remained virtually unchanged since they first appeared in the Cambrian period, more than five hundred million years ago. But there does seem to be a drive for organisms to become more highly organized and more efficient in retaining energy, at least when environmental conditions are changing rapidly, as they were before the Cambrian. The evidence indicates that the first primitive anaerobes on Earth were prokaryotes: small, simple cells—just cytoplasm, usually bounded by a cell wall, but with little if any internal structure.