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Like many theoretically preventable failures, the basic failure at the Emergent BioSolutions plant was not an isolated incident but reflected a problematic safety culture, as suggested by the following reported events: Earlier vaccine lots had also been thrown out for contamination. Mold was a persistent problem in areas that were supposed to be kept immaculately clean. Supervision and training were scant for the many new hires needed to handle the mammoth vaccine production. Although vaccine manufacturing is known as a ā€œfickleā€ business and some error is inevitable, the reports suggested a pattern of lapses had led to the high-profile contamination of millions of doses. When inattention becomes a cultural feature in an organization, you have a breeding ground for producing basic and complex failures alike. Fatigue plays a role in slips due to inattention. The U.S. Centers for Disease Control and Prevention (CDC) reports that a third of adult Americans do not get enough sleep. Such alarming sleep deprivation not only leads to an array of health concerns, but also to accidents and injuries. To cite one example, investigators found that 40 percent of highway accidents identified human fatigue as a ā€œprobable cause, a contributing factor, or a finding,ā€ despite the fact that the National Transportation Safety Board (NTSB) has made 205 fatigue-specific recommendations since the early 1970s.