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Reducing complex failures starts with paying attention to what I call ambiguous threats. Whereas clear threats (a Category 5 hurricane will hit your neighborhood tomorrow) readily trigger corrective action (evacuate your house), we tend to downplay ambiguous threats—missing chances to prevent harm. Downplaying ambiguous threats is the opposite of what occurs in high reliability organizations. I’ve observed this downplaying in settings ranging from the NASA Space Shuttle program to Wall Street to pharmaceutical drug development. What do to these disparate settings have in common in addition to complexity? High stakes and a drive to succeed—a drive so powerful it blinds people to subtle warning signals.