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To aim for zero harm in complex systems such as hospitals is not the same as aiming to erase human error. To err is human. Error will always be with us. But we can design social systems that make everyone aware of the inevitability of error and poised to catch and correct it before it causes harm. That means understanding that Swiss cheese holes sometimes line up—despite being separated by time or distance—to create a tunnel through which complex failure flows unimpeded.